Search results for "polymer conjugates"
showing 3 items of 3 documents
Chemical Strategies for the Synthesis of Protein–Polymer Conjugates
2012
Protein-polymer conjugates have achieved tremendous attention in the last few years. The synergistic combination of properties has led to certain advantages in bio-applications. Over the past few years, numerous chemical strategies have been developed to conjugate different synthetic polymers onto proteins, most of which can be summarized within the scope of click-chemistry. Here we highlight conjugation strategies based on available functional groups present on the synthetic polymer and existing groups of proteins from the natural pool. In particular, the chapter organizes the various possible reactions by classes of functional groups present on protein surfaces, deriving from selected ami…
Polymer Drug Conjugates for the Treatment of Neurodegenerative Disorders
2013
Nanociencia y nanotecnología son la base de técnicas innovadoras para el transporte de fármacos con beneficios potenciales para el paciente y nuevos mercados para la industria. La obtención de nuevos sistemas de transporte de fármacos más efectivos es uno de los principales retos actuales, junto con la mejora del diagnóstico tanto in vitro como in vivo y el desarrollo de tecnologías para la ingeniería tisular y la medicina regenerativa. Además de ser necesario disponer de moléculas con actividad farmacológica para conseguir terapias efectivas se necesitan su transporte y liberación controlada para llegar a conseguir tratamientos con mayor índice terapéutico. El uso de estrategias de direcci…
Chemical conjugation of dexamethasone to a polyaspartamide and in vitro evaluation studies
2004
Two macromolecular conjugates of dexamethasone containing different drug amounts were synthesized using PHEA as the polymeric carrier and a succinic group as spacer. The content of linked drug was equal to 25.3% w/w (conjugate A) and 12.7% w/w (conjugate B). Both polymeric conjugates, unlike the free drug, were water-soluble and the amount of unlinked drug was evaluated to be approximately about 0.01% w/w. Both conjugates were relatively stable in vitro at pH 7.4 whereas in the presence of esterase only the conjugate B was able to release drug under the used experimental conditions. This dissimilar behavior has been attributed to the distinct macromolecular conformations assumed in aqueous …